Can’t smell the virus: SARS-CoV-2, chromatin organization, and anosmia바이러스 냄새를 맡을 수 없음: SARS-CoV-2, 염색질 조직 및 후각 상실Comment Published on 2022-05-092022-09-11 Journal: Developmental cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anosmia Can chromatin organization genomic humans Interaction Loss of Smell mechanism olfactory receptor olfactory receptor gene olfactory receptor genes SARS-CoV-2 SARS-COV-2 infection virus clearance [DOI] 10.1016/j.devcel.2022.04.015 PMC 바로가기 [Article Type] Comment
Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafishSARS-CoV-2 스파이크 단백질의 비강 내 전달은 제브라피쉬에서 후각 손상, 염증 및 후각 기능 장애를 유발하기에 충분합니다Article Published on 2022-05-012022-09-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), SARS, 치료기술, [키워드] animal animal models animals Anosmia bind cause Cell characterized cilia Cluster Combined damage Danio direct infection driven by edema endothelial EOG explained expression fish food functional hemorrhage hemorrhages Histopathology implication indicated Infection Inflammation Inflammatory response Inflammatory responses intranasal intranasally Loss of Smell mechanism myeloid cell nasal epithelium non-neuronal cell non-neuronal cells olfactory Olfactory damage olfactory dysfunction olfactory function Olfactory organ olfactory receptor Olfactory receptor expression organ prevalent Protein RBD receptor reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike SARS-CoV-2 spike protein sensory neuron spike Spike protein Symptom treated Vaccine Viral protein Viral proteins widespread zebrafish Zebrafish (Danio rerio). [DOI] 10.1016/j.bbi.2022.03.006 PMC 바로가기 [Article Type] Article
From musk to body odor: Decoding olfaction through genetic variation사향에서 신체 냄새로 : 유전자 변이를 통해 후각을 해독하는Research Article Published on 2022-02-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation Amino acid amino acid substitutions androstenone Anosmia association Body odor change cis-3-hexen-1-ol coding contribute derived allele ENCODE example explicit functional Galaxolide Genetic genetic diversity Genetic variation Han Chinese human body Hypothesis implication IMPROVE individual information input intensity ionone mechanism musk novel association olfactory olfactory receptor OR4D6 OR51B2 OR5A1 OR7D4 Perception performed phenotype populations Previous studies provide receptor receptors reduced replicated reported robust second shown SNP SNPs trans Variation [DOI] 10.1371/journal.pgen.1009564 PMC 바로가기 [Article Type] Research Article
Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulbArticle Published on 2021-11-242023-06-19 Journal: Cell [Category] MERS, SARS, [키워드] B.1.1.7 coronavirus COVID-19 leptomeninges olfactory bulb olfactory receptor olfactory sensory neuron SARS-CoV-2 sustentacular cell. UGT2A1 [DOI] 10.1016/j.cell.2021.10.027 PMC 바로가기
Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptomSARS-CoV-2 감염 매개체와 말초 후각 수용체의 동시 발현: COVID-19 증상으로서 후각 상실 이상의 잠재적 의미Article Published on 2020-09-012022-09-11 Journal: International journal of molecular medicine [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome adipose Adipose tissue analysed angiotensin Anosmia atlas bladder Brain cathepsin L caused Cell cellular protease Clinical studies clinical study COVID‐19 CTSL damage disease enzyme expressed expression expression profile facilitated function GeneMANIA healthy heart highlight host cells host cells) human host cell human host cells Hyposmia implication in vitro Infection interact kidney liver Local Loss of Smell mechanism mediators nasal New olfactory olfactory bulb olfactory receptor OR51E2 pancrea pancreas periphery plethora Potential Profiling Prostate protease receptor required respiratory Serine serine 2 Severe acute respiratory syndrome significantly Symptom Testis Thyroid tissue tissues TMPRSS2 transmembrane transmembrane protease serine 2 upregulated [DOI] 10.3892/ijmm.2020.4646 PMC 바로가기 [Article Type] Article
Evidence of SARS-CoV2 Entry Protein ACE2 in the Human Nose and Olfactory Bulb인간의 코와 후각구에서 SARS-CoV2 진입 단백질 ACE2의 증거Article Published on 2020-01-012022-09-11 Journal: Cells, tissues, organs [Category] SARS, 치료기술, [키워드] ACE2 anatomical angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anosmia Basal cell basal cells Bulb caused Cell cell type cells Central nervous system clinical cough COVID-19 disease defined dissemination enzyme epithelial cell epithelial cells Evidence evidence of expressed expression expression pattern Fever Human immature Meningitis mild respiratory symptom mild respiratory symptoms nasal Nasal septum Neurological symptoms nose olfactory olfactory bulb Olfactory epithelium olfactory receptor olfactory receptor neuron olfactory receptor neurons organ pandemic paranasal Paranasal sinuses pathway positive Region respiratory respiratory epithelium respiratory symptoms Sagittal section SARS-CoV2 SARS-CoV2. Serine severe symptom severe symptoms sustentacular cells Symptom tissue TMPRSS2 TMPRSS2 protein transmembrane serine protease transmembrane serine protease 2 vice Viral viral meningitis viral tropism [DOI] 10.1159/000513040 PMC 바로가기 [Article Type] Article